Cortopassi Lab-Driven and Collaborative Publications from the last 10 years.

A full list can be found on PubMed under "Cortopassi G"

Date Name of Paper (Click name for description and full access to paper)
Mar, 2025 Robust behavioral assessment of the inducible Friedreich's ataxia mouse does not show improvement with NRF2 induction
Jan, 2025 Poincaré plot analysis of electrocardiogram uncovers beneficial effects of omaveloxolone in a mouse model of Friedreich's ataxia
Dec, 2024 P46Shc Inhibits Mitochondrial ACAA2 Thiolase, Exacerbating Mitochondrial Injury and Inflammation in Aging Livers
Dec, 2024 Differential effects of short-term and long-term ketogenic diet on gene expression in the aging mouse brain
Oct, 2024 Sexual dimorphism in a mouse model of Friedreich's ataxia with severe cardiomyopathy
Sep, 2024 Author Correction: AI is a viable alternative to high throughput screening: a 318-target study
Jul, 2024 Correction to: Lifespan effects in male UM‑HET3 mice treated with sodium thiosulfate, 16‑hydroxyestriol, and late‑start canagliflozin
May, 2024 Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin
Apr, 2024 AI is a viable alternative to high throughput screening: a 318-target study
Feb, 2024 Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes
Feb, 2024 Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
Jan, 2024 Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism
Nov, 2023 The ketone body β-hydroxybutyrate shifts microglial metabolism and suppresses amyloid-β oligomer-induced inflammation in human microglia
May, 2023 Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern
Jan, 2023 Androgen receptor-dependent regulation of metabolism in high grade bladder cancer cells
Sep, 2022 Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic Hepatitis
May, 2022 A Drug Combination Rescues Frataxin-Dependent Neural and Cardiac Pathophysiology in FA Models
Nov, 2021 The Histone H3 K4me3, K27me3, and K27ac Genome-Wide Distributions Are Differently Influenced by Sex in Brain Cortexes and Gastrocnemius of the Alzheimer's Disease PSAPP Mouse Model
Aug, 2021 Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice
Jun, 2021 Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter
May, 2021 17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
Mar, 2021 Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure
Mar, 2021 A ketogenic diet impacts markers of mitochondrial mass in a tissue specific manner in aged mice
Feb, 2021 Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice
Jan, 2021 Repurposing FDA approved drugs inhibiting mitochondrial function for targeting glioma-stem like cells
Nov, 2020 Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells
Oct, 2020 Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity
Jan, 2020 Nonphagocytic Activation of NOX2 Is Implicated in Progressive Nonalcoholic Steatohepatitis During Aging
Nov, 2019 PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection
Oct, 2019 Potential biomarker identification for Friedreich's ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion
Oct, 2019 Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer
Jun, 2019 Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich's Ataxia
Oct, 2018 Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition
Sep, 2018 Small molecules bind human mTOR protein and inhibit mTORC1 specifically
May, 2018 A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
Jan, 2018 Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative
Sep, 2017 A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
Aug, 2017 In Vitro Evaluation of Mitochondrial Function and Estrogen Signaling in Cell Lines Exposed to the Antiseptic Cetylpyridinium Chloride
Aug, 2017 Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans
Apr, 2017 The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells
Apr, 2017 Frataxin deficiency impairs mitochondrial biogenesis in cells, mice and humans
Feb, 2017 Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model
Dec, 2016 Galectin-3 regulates inflammasome activation in cholestatic liver injury
Dec, 2016 Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism
Oct, 2016 A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents
Sep, 2016 Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver
Sep, 2016 Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations
Aug, 2016 Neurobehavioral deficits in the KIKO mouse model of Friedreich's ataxia
Jun, 2016 Lactate and Pyruvate Are Major Sources of Energy for Stallion Sperm with Dose Effects on Mitochondrial Function, Motility, and ROS Production
Jun, 2016 p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria
May, 2016 Mitochondrial oxygen consumption is a unique indicator of stallion spermatozoal health and varies with cryopreservation media
Apr, 2016 Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia
Mar, 2016 Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34
Dec, 2015 Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly
Nov, 2015 Oxidative stress in inherited mitochondrial diseases
Apr, 2015 Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins
Feb, 2015 Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity
Feb, 2015 Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse
Nov, 2014 Mitochondrial complex I defects increase ubiquitin in substantia nigra
Sep, 2014 Shc depletion stimulates brown fat activity in vivo and in vitro
Aug, 2014 Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia
Aug, 2014 Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia
Jul, 2014 High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects
Mar, 2013 Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich's ataxia YG8R mouse model
Feb, 2013 Effects of alkyl side chain modification of coenzyme Q10 on mitochondrial respiratory chain function and cytoprotection
Dec, 2012 Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries
Oct, 2012 OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability
Sep, 2012 Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression
Jun, 2012 Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis
May, 2012 Hepatic Src homology phosphatase 2 regulates energy balance in mice
Dec, 2011 HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis
Dec, 2011 The p66Shc knocked out mice are short lived under natural condition
Nov, 2010 The Shc locus regulates insulin signaling and adiposity in mammals